Thoothukudi lies on the Gulf of Mannar of the Indian Ocean, about 25 miles (40 km) east of Tirunelveli, to which it is connected by road and rail.
The nearest airport is at Vagaikulam about 30 Kms. and the next nearest airport is Madurai about 140 Kms. away from Thoothukudi.
Thoothukudi is well connected by Rail also. Express trains to Chennai, Coimbatore and Mysore are operated daily by the Southern Railways. In addition to this, a passenger train is also operated between Thoothukudi to Tirunelveli daily. The Railway Station is located within the city limits.
It is served by three main roads which radiate to Madurai, Tiruchendur and Tirunelveli. The town is also well connected by the National Highways NH-7A to Tirunelveli , which it turn connects to NH- 7 ( Kanyakumari to Varanasi ). The town is also linked with Mannar Sea. The town is well connected by rail to other parts of the country with linkage to the Harbour. The total length of NH covered in this Corporation is 21 km and the length of SH is about 31.73 km. Regular bus services are also available from all important cities of Tamil Nadu and Kerala.